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Background.&nbsp; When chemical health hazards have been identified, probabilistic dose&ndash;response assessment (&ldquo;hazard characterization&rdquo;) quantifies uncertainty and/or variability in toxicity as a function of human exposure. Existing probabilistic approaches diffe...

Humans interact with thousands of chemicals. This study aims to identify substances of emerging concern and in need of human health risk evaluations. Sixteen pooled human serum samples were constructed from 25 individual samples each from the National Institute of Environmental H...

This is a presentation abstract for proposed session, ID 141, Advances in New Approach Methods for Thyroid Toxicity Testing, for the SOT 2024 Annual Meeting.&nbsp; Abstract: There is significant regulatory need to evaluate chemicals that may disrupt the thyroid endocrine system. ...

Morphogenesis&nbsp;of the blood-brain barrier (BBB) is a complex process linked to&nbsp;neovascularization&nbsp;of the embryonic&nbsp;neural tube. This selective transport interface forms between vascular-neural compartments during&nbsp;organogenesis&nbsp;and dysregulation has be...

Background: Observational epidemiologic studies provide critical data for the evaluation of the potential effects of environmental, occupational and behavioural exposures on human health. Systematic reviews of these studies play a key role in informing policy and practice. System...

To make a dataset FAIR, it is imperative that data sets are internally consistent, nonredundant, unambiguous, and accessible. An example of making FAIR data is provided by the US EPA Integrated Risk Information System (IRIS) Program&rsquo;s inclusion of the Environmental Health V...

A database of embryo-fetal developmental toxicity (EFDT) studies of 379 pharmaceutical compounds in rat and rabbit was analyzed for species differences based on toxicokinetic parameters of area under the curve (AUC) and maximum concentration (Cmax) at the developmental adverse ef...

Per and polyfluoroalkyl substances (PFAS) are a large class of fluorinated organic chemicals of interest to regulatory agencies due to their prevalence and persistence in the environment. Multiple PFAS have been identified as endocrine disrupting chemicals due to estrogen recepto...

Socially isolated individuals and communities often face psychosocial stressors in combination with exposure to high levels of air pollutants. Social isolation (SI) has been considered a risk factor for neuropsychiatric conditions and is also linked to increased metabolic disorde...

Multiple per- and polyfluoroalkyl ether acids have recently been detected in drinking water and/or human serum, but there is a paucity of data on potential toxicity despite known exposure.&nbsp; Perfluoro-2-methoxyacetic acid (PFMOAA) is a short chain ether carboxylate (3 carbons...

Thyroid hormones (TH) are highly iodinated molecules that regulate many aspects of mammalian physiology and are essential for normal growth and development. Deiodinases (DIO) are a family of three metabolizing enzymes (DIO1, DIO2, DIO3) by activating or deactivating TH action. Th...

BACKGROUND. While major pathways of human PFAS exposure are thought to be drinking water and diet, other pathways and sources have also been shown to contribute to a person’s cumulative exposure. However, the degree of contribution of these other sources to PFAS body burdens is s...

Abstract reduced to fit RAPID character limits - full abstract attached Background and Purpose Recent human and ecological biomonitoring studies in the US and China have identified novel perfluoroalkyl carboxylic acids with ether linkages between each fluorinated carbon in a homo...

Background and Purpose: During the sensitive perinatal period, environmental stressors are a threat to brain development. We applied proteomics to investigate the protein changes occurring during the early postnatal rat cerebellum development. Methods: High-resolution mass spect...

Due to the pervasive detection of multiple PFAS in human and environmental matrices, many health-based agencies are employing or pursuing cumulative assessment and regulatory approaches.&nbsp; However, the literature is lacking mammalian in vivo studies that test additivity by co...

RATIONALE&nbsp; Air pollution exposure in pregnancy may affect fetal growth, and fetal growth restriction (FGR) is associ&shy;ated with lung im&shy;pairment that can persist into adulthood. Associated diseases include asthma, pulmonary hypertension (PH), and chronic obstructive p...

The period of neurodevelopment is vulnerable to various insults, including those produced by environmental compounds. We have previously observed behavioral alterations (uncoordinated hindlimb gait, decreased startle response, altered motor activity ontogeny) following perinatal ...

Background: We have previously observed altered ontogeny of locomotor activity and uncoordinated hindlimb gait and decreased startle response in adult animals following perinatal exposure to emamectin benzoate (EB), which acts as a positive allosteric modulator for GABA-gated chl...

Neurite outgrowth is an important precursor to synapse formation and assays for neurite outgrowth are part of an in vitro battery (IVB) of assays for developmental neurotoxicity screening (DNT). This battery of assays evaluates chemical effects on key neurodevelopmental processes...

Assaying for thyroid interference is of increasing importance in standardized developmental and reproductive toxicity studies. While serum T4 quantification is an endpoint assessed in developing rats, it is unclear how this measure may correlate to adverse neurodevelopmental outc...

Systematic evidence mapping for PFAS structures to characterize human health literature for 430 prioritized PFAS. Systematic evidence maps are pre-decisional analyses that use systematic review methods to compile and summarize evidence, but do not include hazard assessment or tox...

Background and Purpose That humans vary in response to environmental chemical exposures has long been appreciated. Even in cases of very high pollutant exposure, the range of health effect responses across individuals varies widely, with subsets of the population showing no respo...

Tracking chemical flows and collecting life cycle inventories (LCI) are crucial steps for identifying potential exposure scenarios at the chemical end-of-life (EoL) stage. Nonetheless, addressing these tasks is time-consuming and challenging. Data-driven modeling is considered a ...

Underground Storage Tanks and EJ Presentation for Region 2 and Community Engaged Research Collaborative for Learning and Excellence.  Community level model to assess cumulative impacts and effectiveness of multi-media interventions in improving public health and mitigating the e...

Presentation at &ldquo;The Science of PFAS Exposure and Effects on Human Health&rdquo; (December 8,&nbsp;2022&nbsp;webinar) Hosted by ASTHO and EPI Center